Supported Liquid Extraction Products
Cleanert SLE (Supported Liquid Extraction) plates and cartridges contain a high quality modified diatomaceous earth with an ideal surface with large specific area and low activity. Cleanert SLE plates and cartridges are used to extract analytes from bio-analytical, clinical, forensic, environmental and agrochemical samples, it even can replace most of the Liquid/Liquid extraction (LLE).
Supported Liquid Extraction (or Solid Supported Liquid/Liquid Extraction) can be considered as a micro liquidliquid extraction with the same principles of traditional liquid-liquid extraction but performed on high quality modified
diatomaceous earth. The target compounds are extracted from an aqueous phase into an immiscible organic phase.
Benefits compared with LLE method
▲ Improving sample cleanliness and method sensitivity;
▲ The performance of SLE is very simple: Load-Wait-Elute, and easy to automate with exiting automatic device in Labs;
▲ No vigorous shaking and therefore emulsions cannot be formed, and ensure the reproducible results;
▲ The intimate contact between the aqueous sample and organic phases allows very efficient partitioning and improve the recoveries and reproducibility.
Product Specification selection guide
The SLE approach can duplicate any developed LLE method with a few minor adjustment. In general, dilute the sample with buffer or water, follow the max sample loading volume to avoid over loading. For bio-samples such as urine and
plasma, the sample volume can be very small (200 - 400 μL), especially when LC-MS/MS as a final technique for analysis.
For sticky sample, SLE Plus series which using bigger particle size is suggested to improve flow rate also avoid blocking. The bigger particle size is also provide a benefit tool for filtration to get rid of particles and matrix.